Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation

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SYSNO ASEP	0346760
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Raman spectroscopic study on sodium hyaluronate: an effect of proton and gamma irradiation
Author(s)	Synytsya, A. (CZ) Alexa, P. (CZ) Wagner, Richard (UJF-V) Davídková, Marie (UJF-V)_{RID, ORCID, SAI} Volka, K. (CZ)
Number of authors	6
Source Title	Journal of Raman Spectroscopy. - : Wiley - ISSN 0377-0486 Roč. 42, č. 3 (2011), s. 544-550
Number of pages	7 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	sodium hyaluronate ; proton irradiation ; gamma irradiation ; Raman spectroscopy
Subject RIV	CB - Analytical Chemistry, Separation
CEZ	AV0Z10480505 - UJF-V (2005-2011)
UT WOS	000288544000044
DOI	10.1002/jrs.2724
Annotation	Raman spectroscopy was applied to the analysis of structural changes in lyophilised sodium hyaluronate after proton and gamma irradiation (0.5, 5, 50, 100, 200 and 600 Gy). Characteristic Raman bands of the polysaccharide were sensitive to irradiation. Significant damage was observed at doses of 50 Gy or higher. The spectral changes confirmed radiation-induced loss of native solution conformation, destruction of primary structure, fragmentation, cross-linking and elimination of functional groups. Differences in the effects of proton and gamma radiation on sodium hyaluronate are discussed.
Workplace	Nuclear Physics Institute
Contact	Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228
Year of Publishing	2012

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