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Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units
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SYSNO ASEP 0346349 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Supplemented Creatine Induces Changes in Human Metabolism of Thiocompounds and One- and Two-Carbon Units Author(s) Navrátil, Tomáš (UFCH-W) RID, ORCID
Kohlíková, E. (CZ)
Petr, M. (CZ)
Pelclová, D. (CZ)
Heyrovský, Michael (UFCH-W) RID
Přistoupilová, K. (CZ)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 59, č. 3 (2010), s. 431-442Number of pages 12 s. Language eng - English Country CZ - Czech Republic Keywords creatine ; creatinine ; folates ; homocysteine Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects IAA400400806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000280363700016 Annotation The administration of creatine (5 g/day for one month) to 11 young active sportsmen affected their urinary excretion of creatine, creatinine, and thiodiglycolic acid (TDGA) as well as blood levels of homocysteine, vitamin B-12 and folates. The probands were divided into four groups, according to the amount of creatine found in urine, and of folates and vitamin B-12 determined in blood. The changes of folates and vitamin B-12 were mutually reciprocal. Each group utilized CR as donor of one- and two-carbon (1C and 2C) units by means of homocysteine (HoCySH), folates, and vitamin B-12, in different metabolic pathways. In 10 men the creatine administration was accompanied by an increase of HoCySH level in blood, while in the last man, with accidentally discovered hyperhomocysteinemia, the HoCySH level dropped by 50 %. Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2011
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