Number of the records: 1
Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids
- 1.
SYSNO ASEP 0346335 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and GABAA receptor activity of A-homo analogues of neuroactive steroids Author(s) Dansey, M. V. (AR)
Di Chenna, P. (AR)
Valeiro, A. S. (AR)
Krištofíková, Z. (CZ)
Chodounská, Hana (UOCHB-X) RID, ORCID
Kasal, Alexander (UOCHB-X)
Burton, G. (AR)Number of authors 7 Source Title European Journal of Medicinal Chemistry. - : Elsevier - ISSN 0223-5234
Roč. 45, č. 7 (2010), s. 3063-3069Number of pages 7 s. Language eng - English Country FR - France Keywords A-homopregnane ; neurosteroid ; gamma-aminobutyric acid ; GABAA receptor Subject RIV CC - Organic Chemistry R&D Projects GA203/08/1498 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000278626400044 DOI 10.1016/j.ejmech.2010.03.037 Annotation A-Homo-5-pregnenes were prepared and their inhibition of binding TBPS to GABAA receptors was measured. 3alpha-Hydroxy and 4alpha-hydroxy analogues of allopregnanolone were slightly active while the 3beta-hydroxy analogue was almost as active as allopregnanolone. Reduction of the double bond of the latter compound resulted in a ten fold loss of activity. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
Number of the records: 1