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The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability
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SYSNO ASEP 0346290 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability Author(s) Elbert, Tomáš (UOCHB-X) RID, ORCID
Břehová, Petra (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)Number of authors 3 Source Title Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765
Roč. 75, č. 7 (2010), s. 757-766Number of pages 10 s. Language eng - English Country CZ - Czech Republic Keywords tritium ; 3-H NMR ; acyclic nucleotide analogues Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA400550801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000280518100004 DOI 10.1135/cccc2010020 Annotation 9-(2-Phosphonomethoxyethyl)-2,6-diamino-[8-3H]purine, 9-(2-phosphonomethoxyethyl)- [8-3H]guanine and (R)- 9-(2-phosphonomethoxypropyl)-[8-3H]adenine with specific activities of 10.9 Ci/mmol, 7.9 Ci/mmol and 16 Ci/mmol, respectively, were prepared by a catalytic dehalogenation of the corresponding 8-bromo derivatives. The rate of the exchange of the tritium label on C-8 of the purine ring in title compounds with the hydrogen of water under physiological pH at 20 °C was studied using 3H NMR. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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