Number of the records: 1
Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base
- 1.
SYSNO ASEP 0345964 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and biological evaluation of acyclic nucleotide analogues with a furo[2,3-d]pyrimidin-2(3H)-one base Author(s) Janeba, Zlatko (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)
Pohl, Radek (UOCHB-X) RID, ORCID
Snoeck, R. (BE)
Andrei, G. (BE)
De Clercq, E. (BE)
Balzarini, J. (BE)Number of authors 7 Source Title Canadian Journal of Chemistry. - : Canadian Science Publishing - ISSN 0008-4042
Roč. 88, č. 7 (2010), s. 628-638Number of pages 11 s. Language eng - English Country CA - Canada Keywords acyclic nucleoside phosphonates ; Sonogashira reaction ; intramolecular cyclization Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000279739100007 DOI 10.1139/V10-054 Annotation A novel series of 2-(phosphonomethoxy)ethyl (PME) substituted furo[2,3-d]pyrimidin-2(3H)-ones with potential anti-VZV and/or anti-HCMV activity was synthesized. The target acyclic nucleotide analogues were prepared by Sonogashira coupling of protected 5-iodo-1-[2-(phosphonomethoxy)ethyl]uracil with various 1-alkynes, followed by in situ Cu(I)-promoted intramolecular cyclization and standard removal of the isopropyl ester groups. None of the prepared analogues were active at subtoxic concentrations against VZV thymidine kinase competent (TK+), VZV thymidine kinase deficient (TK–), or HCMV. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
Number of the records: 1