Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension

Líšková, Silvia; Petrová, M.; Karen, Petr; Kuneš, Jaroslav; Zicha, Josef

doi:https://dx.doi.org/10.1016/j.jash.2010.02.006

Number of the records: 1

Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension

1.

SYSNO ASEP	0345854
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension
Author(s)	Líšková, Silvia (FGU-C) Petrová, M. (SK) Karen, Petr (FGU-C) Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	Journal of the American Society of Hypertension. - : Elsevier - ISSN 1933-1711 Roč. 4, č. 3 (2010), s. 128-134
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	potassium channels ; nitric oxide ; norepinephrine
Subject RIV	ED - Physiology
R&D Projects	IAA500110902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000278115200004
DOI	10.1016/j.jash.2010.02.006
Annotation	The activation of Ca2+-dependent K+ channels (BKCa) leads to the attenuation of vascular contraction. Our study aimed to evaluate BKCa influence on norepinephrine (NE)-induced femoral artery contraction in two forms of genetic hypertension. NO-dependent attenuation of NE-induced contractions was greater in SHR than HTG or Wistar vessels, whereas large conductance Ca2+-dependent K+ channels may play a greater role in modulating vascular contraction in the severe form of hypertension
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1