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Effects of gamma irradiation on the DNA-protein complex between the estrogen response element and the estrogen receptor
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SYSNO ASEP 0345749 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effects of gamma irradiation on the DNA-protein complex between the estrogen response element and the estrogen receptor Author(s) Štísová, Viktorie (UJF-V)
Goffinont, S. (FR)
Maurizot, M. S. (FR)
Davídková, Marie (UJF-V) RID, ORCID, SAISource Title Radiation Physics and Chemistry. - : Elsevier - ISSN 0969-806X
Roč. 79, č. 8 (2010), s. 880-889Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords DNA-protein complex ; estrogen response element ; estrogen receptor ; ionizing radiation Subject RIV BO - Biophysics R&D Projects 1P05OC085 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC09012 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000278425800012 DOI 10.1016/j.radphyschem.2010.03.009 Annotation The radiosensitivity in vitro of the complex between ER alpha, a subtype of this receptor, and a DNA fragment bearing ERE, as well as the influence of an estrogen (estradiol) or an anti-estrogen (tamoxifen) on this radiosensitivity were studied. We observed that the complex is destabilized upon irradiation with gamma rays in aerated aqueous solution. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2011
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