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Role of matrix metalloproteinases in recurrent corneal melting
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SYSNO ASEP 0345733 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Role of matrix metalloproteinases in recurrent corneal melting Author(s) Brejchová, K. (CZ)
Lisková, P. (CZ)
Čejková, Jitka (UEM-P) RID
Jirsová, K. (CZ)Source Title Experimental Eye Research. - : Elsevier - ISSN 0014-4835
Roč. 90, č. 5 (2010), s. 583-590Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords corneal melting ; extracellular matrix degradation ; matrix metalloproteinases Subject RIV FF - HEENT, Dentistry CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000276988200007 DOI 10.1016/j.exer.2010.02.002 Annotation The aim of the study was to investigate the role of metalloproteinases (MMPs - 1,- 2, -3, -4, -5,- 6,- 7, -8,- 9 and -13) during corneal melting in humans. The markety increased immunostaining for MMPS -1,- 2,- 3, -7, -8 and -9 and increased levels of the activity of MMP-1, -2, -3 and -9 in melted corneas of patiens suffering from various ocular diseases suggest that metalloproteinases play very important role in the destruction of extracellular matrix leading to corneal melting. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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