Number of the records: 1

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors

SYSNO ASEP	0345730
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors
Author(s)	Šála, Michal (UOCHB-X)_{RID, ORCID} De Palma, A. M. (BE) Hřebabecký, Hubert (UOCHB-X)_{RID, ORCID} Nencka, Radim (UOCHB-X)_{RID, ORCID} Dračínský, Martin (UOCHB-X)_{RID, ORCID} Leyssen, P. (BE) Neyts, J. (BE) Holý, Antonín (UOCHB-X)
Number of authors	8
Source Title	Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896 Roč. 18, č. 12 (2010), s. 4374-4384
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	6-chloropurine ; coxsackievirus B3 ; bicyclo[2.2.1]heptane
Subject RIV	CC - Organic Chemistry
R&D Projects	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000278480900021
DOI	10.1016/j.bmc.2010.04.081
Annotation	Novel class of coxsackievirus inhibitors derived from a bicyclo[2.2.1]heptane was synthetised and target compounds were tested for antiviral activity against coxsackievirus B3. Most analogues showed activity in the low micromolar range with minimal cytotoxicity.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2011

Number of the records: 1