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Noise exposure during early development impairs the processing of sound intensity in adult rats
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SYSNO ASEP 0345712 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Noise exposure during early development impairs the processing of sound intensity in adult rats Author(s) Bureš, Zbyněk (UEM-P) RID, ORCID
Grécová, Jolana (UEM-P)
Popelář, Jiří (UEM-P) RID
Syka, Josef (UEM-P) RIDSource Title European Journal of Neuroscience - ISSN 0953-816X
Roč. 32, č. 1 (2010), s. 155-164Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords auditory system ; critical period ; inferior colliculus Subject RIV FH - Neurology R&D Projects GA309/07/1336 GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000279612400017 DOI 10.1111/j.1460-9568.2010.07280.x Annotation The study demonstrates that exposure to intense noise at postnatal day 14 produced not only poorer frequency selectivity of neurons in the inferior colliculus (as reported previously by Grecova et al. (2009) Eur. J. Neurosci. 29, 1921–1930), but affected significantly the neuronal representation of sound intensity. Although the response thresholds were similar in the exposed and control rats, the neurons in the exposed animals had a longer first-spike latency, a narrower dynamic range, lower maximum response magnitudes and a steeper slope of the rate–intensity functions. The observed anomalies were confined to the mid- and high-frequency regions, whereas no significant changes were found in the low-frequency neurons. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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