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Inactivation of the left auditory cortex impairs temporal discrimination in the rat
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SYSNO ASEP 0345711 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Inactivation of the left auditory cortex impairs temporal discrimination in the rat Author(s) Rybalko, Natalia (UEM-P) RID
Šuta, Daniel (UEM-P) RID
Popelář, Jiří (UEM-P) RID
Syka, Josef (UEM-P) RIDSource Title Behavioural Brain Research. - : Elsevier - ISSN 0166-4328
Roč. 209, č. 1 (2010), s. 123-130Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords auditory cortex ; temporal discrimination ; hemispheric lateralization Subject RIV FH - Neurology R&D Projects GA309/07/1336 GA ČR - Czech Science Foundation (CSF) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000276582900018 DOI 10.1016/j.bbr.2010.01.028 Annotation The ability of rats to detect or discriminate a series of gaps in continuous noise under conditions of unilateral or bilateral reversible inactivation of the auditory cortex (AC) is studied with the aim to explore the hemispheric lateralization of acoustical signal processing in non-human mammals. The results showed that muscimol-induced reversible inactivation of the left AC suppresses the ability of rats to discriminate between acoustical stimuli of different temporal parameters, whereas inactivation of the right AC results in no change or only a mild decrease in discrimination ability. Our findings demonstrate that, similarly as in humans, the left AC in the rat plays the dominant role in temporal discrimination. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
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