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Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles
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SYSNO ASEP 0345370 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles Author(s) Zerzánková, Lenka (BFU-R)
Suchánková, T. (CZ)
Vrána, Oldřich (BFU-R) RID
Farrell, N.P. (US)
Brabec, Viktor (BFU-R) RID, ORCIDNumber of authors 5 Source Title Biochemical Pharmacology. - : Elsevier - ISSN 0006-2952
Roč. 79, č. 2 (2010), s. 112-121Number of pages 10 s. Language eng - English Country US - United States Keywords antitumor ; dinuclear platinum complex ; DNA damage Subject RIV BO - Biophysics R&D Projects LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000273506900004 DOI 10.1016/j.bcp.2009.08.009 Annotation A detailed biochemical and molecular biophysics study of the molecular mechanism of action of a new dinuclear PtII complex [{PtCl(1,2-diaminocyclohexane)}2-my-Y]4+, resistant to decomposition by sulfur nucleophiles, was reported herein. The results show that this complex exhibits promising antitumor features as its DNA adducts can largely escape repair and inhibit very effectively transcription. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2011
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