Number of the records: 1

Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells

SYSNO ASEP	0345305
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells
Author(s)	Valovičová, Z. (SK) Marvanová, S. (CZ) Mészárosová, M. (SK) Srančíková, A. (SK) Trilecová, L. (CZ) Milcová, A. (CZ) Líbalová, H. (CZ) Vondráček, Jan (BFU-R)_{RID, ORCID} Machala, M. (CZ) Topinka, J. (CZ) Gábelová, A. (SK)
Number of authors	11
Source Title	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107 Roč. 665, 1-2 (2009), s. 51-60
Number of pages	10 s.
Language	eng - English
Country	NL - Netherlands
Keywords	DNA adducts ; DNA strand breaks ; oxidative stress
Subject RIV	BO - Biophysics
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000266690200008
DOI	10.1016/j.mrfmmm.2009.02.014
Annotation	In the present study we demonstrated qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 liver cells. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC derivative.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1