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A potent cytotoxic photoactivated platinum complex

SYSNO ASEP	0345270
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	A potent cytotoxic photoactivated platinum complex
Author(s)	Mackay, F.S. (GB) Woods, J.A. (GB) Heringová, Pavla (BFU-R) Kašpárková, Jana (BFU-R)_{RID, ORCID} Pizarro, A.M. (GB) Moggach, S.A. (GB) Parsons, S. (GB) Brabec, Viktor (BFU-R)_{RID, ORCID} Sadler, P.J. (GB)
Number of authors	9
Source Title	Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424 Roč. 104, č. 52 (2007), s. 20743-20748
Number of pages	6 s.
Language	eng - English
Country	US - United States
Keywords	cytotoxicity ; DNA binding ; photochemistry
Subject RIV	BO - Biophysics
R&D Projects	GA305/05/2030 GA ČR - Czech Science Foundation (CSF)
	GD204/03/H016 GA ČR - Czech Science Foundation (CSF)
	NR8562 GA MZd - Ministry of Health (MZ)
	1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000252077400024
DOI	10.1073/pnas.0707742105
Annotation	Platinum(IV)diazido complexes containing cis-diam(m)ine ligands are relatively inert in the dark. We report here the dramatic effects arising from incorporation of a pyridine ligand in place of an ammine ligand. trans,trans,trans-[Pt(N3)2(OH)2(NH3)(py)] is highly phototoxic and reacts with guanine derivatives and with DNA to give unusual PtII adducts not readily formed in the absence of light.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1