The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance

Atanur, S. S.; Birol, I.; Guryev, V.; Hirst, M.; Hummel, O.; Morrissey, C.; Behmoaras, J.; Fernandez-Suarez, X.M.; Johnson, M. D.; McLaren, W. M.; Patone, G.; Petretto, E.; Plessy, Ch.; Rockland, K. S.; Rockland, Ch.; Saar, K.; Zhao, Y.; Carninci, P.; Flicek, P.; Kurtz, T.; Cuppen, E.; Pravenec, Michal; Hubner, N.; Jones, S. J. M.; Birney, E.; Aitman, T. J.

doi:https://dx.doi.org/10.1101/gr.103499.109

Number of the records: 1

The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance

1.

SYSNO ASEP	0345074
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance
Author(s)	Atanur, S. S. (GB) Birol, I. (CA) Guryev, V. (NL) Hirst, M. (CA) Hummel, O. (DE) Morrissey, C. (US) Behmoaras, J. (GB) Fernandez-Suarez, X.M. (GB) Johnson, M. D. (US) McLaren, W. M. (GB) Patone, G. (DE) Petretto, E. (GB) Plessy, Ch. (JP) Rockland, K. S. (JP) Rockland, Ch. (JP) Saar, K. (DE) Zhao, Y. (CA) Carninci, P. (JP) Flicek, P. (GB) Kurtz, T. (US) Cuppen, E. (NL) Pravenec, Michal (FGU-C)_{RID, ORCID} Hubner, N. (DE) Jones, S. J. M. (CA) Birney, E. (GB) Aitman, T. J. (GB)
Source Title	Genome Research. - : Cold Spring Harbor Laboratory Press - ISSN 1088-9051 Roč. 20, č. 6 (2010), s. 791-803
Number of pages	13 s.
Language	eng - English
Country	US - United States
Keywords	spontaneously hypertensive rat ; genome sequence ; genetics
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000278269400010
DOI	10.1101/gr.103499.109
Annotation	The spontaneously hypertensive rat (SHR) is the most widely studied animal model of hypertension. Scores of SHR quantitative loci (QTLs) have been mapped for hypertension and other phenotypes. We have sequenced the SHR/OlaIpcv genome at 10.7-fold coverage by paired-end sequencing on the Illumina platform. This near complete catalog of genomic differences between two extensively studied rat strains provides the starting point for complete elucidation, at the molecular level, of the physiological and pathophysiological phenotypic differences between individuals from these strains
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1