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Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

SYSNO ASEP	0345059
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice
Author(s)	Machová, Eva (FGU-C) Rudajev, Vladimír (FGU-C)_RID Smyčková, Helena (FGU-C) Koivisto, H. (FI) Tanila, H. (FI) Doležal, Vladimír (FGU-C)_{RID, ORCID}
Source Title	Neurobiology of Disease. - : Elsevier - ISSN 0969-9961 Roč. 38, č. 1 (2010), s. 27-35
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	Alzheimer´s disease ; acetylcholine release ; amyloid
Subject RIV	CE - Biochemistry
R&D Projects	IAA500110703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000275812700004
DOI	10.1016/j.nbd.2009.12.023
Annotation	We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its onset. Our results indicate that functional pre- and postsynaptic cholinergic deficits are nor present in APPswe/PS1dE9 transgenic mice before 10 weeks of age, but develop along with beta-amyloid accumulation in the brain
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1