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High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro
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SYSNO ASEP 0345018 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro Author(s) Jiruška, P. (GB)
Csicsvari, J. (GB)
Powell, A.V. (GB)
Fox, J.E. (GB)
Chang, W.C. (GB)
Vreugdenhil, M. (GB)
Li, X. (GB)
Paluš, Milan (UIVT-O) RID, SAI, ORCID
Bujan, A.F. (GB)
Dearden, R.W. (GB)
Jefferys, J. G. R. (GB)Source Title Journal of Neuroscience. - : Society for Neuroscience - ISSN 0270-6474
Roč. 30, č. 16 (2010), s. 5690-5701Number of pages 12 s. Language eng - English Country US - United States Keywords mammalian hippocampus invitro ; temporal-lobe epilepsy ; nonsynaptic epileptogenesis ; spatiotemporal dynamics ; after-discharges ; pyramidal cells ; oscillations ; rat ; calcium ; slice Subject RIV FH - Neurology CEZ AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000276923700021 EID SCOPUS 77951609782 DOI 10.1523/JNEUROSCI.0535-10.2010 Annotation How seizures start is a major question in epilepsy research. We demonstrate the existence of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) and reduction in system complexity. Transition to seizure is characterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2011
Number of the records: 1