Number of the records: 1
High-LET Radiation-Induced Response of Microvessels in the Hippocampus
- 1.
SYSNO ASEP 0344033 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title High-LET Radiation-Induced Response of Microvessels in the Hippocampus Author(s) Mao, X. W. (US)
Favre, C. J. (US)
Fike, J. R. (US)
Kubínová, Lucie (FGU-C) RID, ORCID
Anderson, E. (US)
Campbell-Beachler, M. (US)
Jones, T. (US)
Smith, A. (US)
Rightnar, S. (US)
Nelson, G. A. (US)Source Title Radiation Research. - : Radiation Research Society - ISSN 0033-7587
Roč. 173, č. 4 (2010), s. 486-493Number of pages 8 s. Language eng - English Country US - United States Keywords hippocampus ; stereology ; microvessels Subject RIV EA - Cell Biology CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000276472800011 DOI 10.1667/RR1728.1 Annotation Endothelial population changes in hippocampal microvessels exposed to 56Fe ions at doses of 0, 0.5, 2 and 4 Gy were quantified using unbiased stereological techniques. Twelve months after exposure, mice that received 0.5 Gy or 2 Gy of iron ions showed a 34% or 29% loss of endothelial cells, respectively, in the hippocampal cornu ammonis region 1 (CA1) compared to age-matched controls or mice that received 4 Gy. In contrast to the CA1, in the dentate gyrus (DG), there was no significant difference in microvessel cell and length density between irradiated groups and age-matched controls. Vascular topology differences between CA1 and DG may account for the variation in dose response Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
Number of the records: 1