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Serotonin and its 5-HT2 receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils

SYSNO ASEP	0343868
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Serotonin and its 5-HT2 receptor agonist DOI hydrochloride inhibit the oxidative burst in total leukocytes but not in isolated neutrophils
Author(s)	Prachařová, Lucie (BFU-R) Okénková, Kateřina (BFU-R) Lojek, Antonín (BFU-R)_RID Číž, Milan (BFU-R)_{RID, ORCID}
Number of authors	4
Source Title	Life Sciences. - : Elsevier - ISSN 0024-3205 Roč. 86, 13-14 (2010), s. 518-523
Number of pages	6 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	chemiluminescence ; oxidative burst ; serotonin
Subject RIV	BO - Biophysics
R&D Projects	GA524/07/1511 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000276142300009
DOI	10.1016/j.lfs.2010.02.003
Annotation	It was observed that 5-HT and its 5-HTR2 agonist DOI hydrochloride were able to inhibit the luminol-enhanced CL response in activated rat and human total leukocytes, but not in isolated human PMNL. The interpretation of these results could suggest the indirect involvement of 5-HTR2 expressed not on the neutrophil surface but on the surface of other leukocytes.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2011

Number of the records: 1