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Proinflammatory Status, Genetics and Atherosclerosis
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SYSNO ASEP 0343802 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Proinflammatory Status, Genetics and Atherosclerosis Author(s) Poledne, R. (CZ)
Lorenzová, A. (CZ)
Stávek, P. (CZ)
Valenta, Zdeněk (UIVT-O) RID, SAI, ORCID
Hubáček, J. (CZ)
Suchánek, R. (CZ)
Piťha, J. (CZ)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 58, Suppl. 2 (2009), S111-S118Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords atherosclerosis ; inflammation ; C-reactive protein ; genetics Subject RIV EB - Genetics ; Molecular Biology R&D Projects 1M06014 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000273537200012 EID SCOPUS 77949516701 DOI 10.33549/physiolres.931915 Annotation C-reactive protein concentration analyzed by high sensitivity method (hsCRP) represents a known marker of premature atherosclerosis. Higher concentrations represent an increased individual risk of myocardial infarction and stroke. In a representative sample of the Czech population, a positive relation of hsCRP to BMI, a waist circumference and triglyceride concentration was documented. Substantial sex differences were found in its relationship to age. Whereas it is continuously increasing in men, this increase appears in women only after menopause. A substantial decrease of body weight and visceral fat volume by increased physical activity is accompanied by significant decrease of hsCRP in young obese women. We hypothesized that an increased concentration of hsCRP represents a certain marker of proinflammatory status related to central obesity and triglyceride metabolism and it might be related to individual properties of monocytes in atherogenesis Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2011
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