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Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study

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    SYSNO ASEP0343468
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleExpression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
    Author(s) Vrajová, M. (CZ)
    Šťastný, František (FGU-C)
    Horáček, J. (CZ)
    Lochman, J. (CZ)
    Šerý, O. (CZ)
    Peková, S. (CZ)
    Klaschka, Jan (UIVT-O) RID, SAI, ORCID
    Höschl, C. (CZ)
    Source TitleNeurochemical Research - ISSN 0364-3190
    Roč. 35, č. 7 (2010), s. 994-1002
    Number of pages9 s.
    Languageeng - English
    CountryUS - United States
    Keywordsschizophrenia ; hippocampus ; GluN1 subunit of NMDA receptor ; splice variants ; laterality
    Subject RIVFL - Psychiatry, Sexuology
    CEZAV0Z50110509 - FGU-C (2005-2011)
    AV0Z10300504 - UIVT-O (2005-2011)
    UT WOS000278411000005
    EID SCOPUS77953231677
    DOI10.1007/s11064-010-0145-z
    AnnotationThere is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients.
    WorkplaceInstitute of Computer Science
    ContactTereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800
    Year of Publishing2011