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Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
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SYSNO ASEP 0343468 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study Author(s) Vrajová, M. (CZ)
Šťastný, František (FGU-C)
Horáček, J. (CZ)
Lochman, J. (CZ)
Šerý, O. (CZ)
Peková, S. (CZ)
Klaschka, Jan (UIVT-O) RID, SAI, ORCID
Höschl, C. (CZ)Source Title Neurochemical Research. - : Springer - ISSN 0364-3190
Roč. 35, č. 7 (2010), s. 994-1002Number of pages 9 s. Language eng - English Country US - United States Keywords schizophrenia ; hippocampus ; GluN1 subunit of NMDA receptor ; splice variants ; laterality Subject RIV FL - Psychiatry, Sexuology CEZ AV0Z50110509 - FGU-C (2005-2011) AV0Z10300504 - UIVT-O (2005-2011) UT WOS 000278411000005 EID SCOPUS 77953231677 DOI 10.1007/s11064-010-0145-z Annotation There is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2011
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