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Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids
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SYSNO ASEP 0343394 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids Author(s) Hocková, Dana (UOCHB-X) RID, ORCID
Dračínský, Martin (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)Number of authors 3 Source Title European Journal of Organic Chemistry - ISSN 1434-193X
-, č. 15 (2010), s. 2885-2892Number of pages 8 s. Language eng - English Country DE - Germany Keywords nucleotides ; phosphonates ; cross-coupling Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000278611900009 DOI 10.1002/ejoc.201000061 Annotation A series of novel acyclic nucleoside phosphonates with a built-in arylphosphonate moiety has been prepared by a microwave-assisted cross-coupling reaction as the key step. Their cytostatic and antiviral activities were tested. The pKa values of the target ortho-, meta- and para-substituted arylphosphonates were determined by 31P NMR titration studies. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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