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Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin

SYSNO ASEP	0343342
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin
Author(s)	Pintérová, Mária (FGU-C) Karen, Petr (FGU-C) Kuneš, Jaroslav (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI}
Source Title	Journal of Hypertension. - : Lippincott Williams & Wilkins - ISSN 0263-6352 Roč. 28, č. 5 (2010), s. 969-978
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	calcium channels ; inhibitory G proteins ; pertussis toxin
Subject RIV	FA - Cardiovascular Diseases incl. Cardiotharic Surgery
R&D Projects	1M0510 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA305/08/0139 GA ČR - Czech Science Foundation (CSF)
	IAA500110902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000276706500015
DOI	10.1097/HJH.0b013e328335dd49
Annotation	The overexpression of pertussis toxin (PTX)-sensitive inhibitory G-proteins (Gi) participating in the development and maintenance of high BP in SHRs suggested us to study Gi-protein involvement in the pathway through which noradrenergic vasoconstriction and calcium influx can be coupled. PTX pretreatment of SHRs significantly decreased BP and reduced sympathetic vasoconstriction, which was partially substituted by enhanced angiotensin II-dependent vasoconstriction. PTX pretreatment of SHRs also decreased BP component sensitive to acute blockade of calcium entry by nifedipine. Thus the enhanced contribution of SNS to hypertension maintenance in SHRs is mediated by Gi-protein-coupled pathway controlling calcium influx through L type of voltage-dependent calcium channels
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1