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The Acyclic 2,4-Diaminopyrimidine Nucleoside Phosphonate Acts as a Purine Mimetic in HIV-1 Reverse Transcriptase DNA Polymerization

SYSNO ASEP	0343318
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The Acyclic 2,4-Diaminopyrimidine Nucleoside Phosphonate Acts as a Purine Mimetic in HIV-1 Reverse Transcriptase DNA Polymerization
Author(s)	Herman, B. D. (US) Votruba, Ivan (UOCHB-X)_RID Holý, Antonín (UOCHB-X) Sluis-Cremer, N. (US) Balzarini, J. (BE)
Number of authors	5
Source Title	Journal of Biological Chemistry. - : Elsevier - ISSN 0021-9258 Roč. 285, č. 16 (2010), s. 12101-12108
Number of pages	8 s.
Language	eng - English
Country	US - United States
Keywords	acyclic nucleotide analogue ; purine open ring ; HIV-1 RT ; antiviral ; antimetabolite
Subject RIV	CC - Organic Chemistry
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000276787100040
DOI	10.1074/jbc.M109.096529
Annotation	HIV-1 RT recognizes diphosphate of the acyclic pyrimidine nucleoside phosphonate (ANP) phosphonylmethoxyethoxydiaminopyrimidine (PMEO-DAPym) as purine nucleotide analogue. Molecular modeling demonstrates that PMEO-DAPym-pp fits into the active site of HIV-1 RT and incorporates opposite to thymine (in DNA). The data revealed that PMEODAPym represents the prototype compound of a novel class of pyrimidine acyclic nucleoside phosphonates and should form the rational basis for the design and development of novel purine nucleo(s)(t)ide mimetics as potential antiviral or antimetabolic agents.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2011

Number of the records: 1