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A Review on the Effects of Supercritical Carbon Dioxide on Enzyme Activity
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SYSNO ASEP 0343315 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A Review on the Effects of Supercritical Carbon Dioxide on Enzyme Activity Author(s) Wimmer, Zdeněk (UEB-Q) RID, ORCID
Zarevúcka, Marie (UOCHB-X) RIDSource Title International Journal of Molecular Sciences. - : MDPI
Roč. 11, č. 1 (2010), s. 233-253Number of pages 21 s. Language eng - English Country US - United States Keywords enzyme ; supercritical carbon dioxide ; synthesis Subject RIV CC - Organic Chemistry R&D Projects 2B06024 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50380511 - UEB-Q (2005-2011) AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000274000500016 DOI 10.3390/ijms11010233 Annotation Different types of enzymes such as lipases, several phosphatases, dehydrogenases, oxidases, amylases and others are well suited for the reactions in SC-CO2. The stability and the activity of enzymes exposed to carbon dioxide under high pressure depend on enzyme species, water content in the solution and on the pressure and temperature of the reaction system. The three-dimensional structure of enzymes may be significantly altered under extreme conditions, causing their denaturation and consequent loss of activity. If the conditions are less adverse, the protein structure may be largely retained. Minor structural changes may induce an alternative active protein state with altered enzyme activity, specificity and stability. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2011
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