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Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment
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SYSNO ASEP 0343142 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Remodelling of living bone induced by dynamic loading and drug delivery—Numerical modelling and clinical treatment Author(s) Maršík, František (UT-L) RID
Klika, Václav (UT-L) RID
Chlup, Hynek (UT-L)Source Title Mathematics and Computers in Simulation. - : Elsevier - ISSN 0378-4754
Roč. 80, č. 6 (2010), s. 1278-1288Number of pages 13 s. Language eng - English Country NL - Netherlands Keywords bone remodelling ; chemical kinetics ; biochemical model Subject RIV BJ - Thermodynamics R&D Projects GA106/03/1073 GA ČR - Czech Science Foundation (CSF) GA106/08/0557 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z20760514 - UT-L (2005-2011) UT WOS 000276380400024 DOI 10.1016/j.matcom.2009.02.014 Annotation The biomechanical remodelling process is well formulated for bones and is divided into three stages: (1) bone resorption based on the osteoclast activity, (2) bone deposition based on the osteoblast activity and (3) bone growth control established on RANK/RANKL/OPG pathway-RANKL/OPG balance. The main driving force of remodelling process is a dynamic loading (cyclic compression and expansion, e.g. walking or running), which strongly influences the rate of chemical reactions. The evolution from the omogeneous density distribution to the corticalis and cancellous bone formation is shown. An inevitable influence of a dynamic mechanical loading and osteoprotegerin (OPG) concentration is demonstrated. Workplace Institute of Thermomechanics Contact Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Year of Publishing 2011
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