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Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex
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SYSNO ASEP 0342964 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex Author(s) Kubíček, K. (CZ)
Monnet, J. (FR)
Scintilla, S. (IT)
Kopečná, Jana (BC-A)
Arnesano, F. (IT)
Trantírek, Lukáš (BC-A)
Chopard, C. (FR)
Natile, G. (IT)
Kozelka, J. (CZ)Source Title Chemistry-An Asian Journal . - : Wiley - ISSN 1861-4728
Roč. 5, č. 2 (2010), s. 244-247Number of pages 4 s. Language eng - English Country DE - Germany Keywords DNA structures ; interstrand crosslinks ; molecular modeling ; NMR spectroscopy ; platinum Subject RIV BO - Biophysics CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000274539100003 DOI 10.1002/asia.200900655 Annotation An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-diaminocyclohexane)2+ (the enantiomer of the antitumor drug oxaliplatin). The final product provides a rare example of intramolecular self-intercalation of DNA. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2011
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