Number of the records: 1

Nucleotide variability of Ťahyňa virus (Bunyaviridae, Orthobunyavirus) small (S) and medium (M) genomic segments in field strains differing in biological properties

SYSNO ASEP	0342878
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Nucleotide variability of Ťahyňa virus (Bunyaviridae, Orthobunyavirus) small (S) and medium (M) genomic segments in field strains differing in biological properties
Author(s)	Kilian, P. (CZ) Růžek, Daniel (BC-A)_{RID, ORCID} Danielová, V. (CZ) Hypša, Václav (BC-A)_RID Grubhoffer, Libor (BC-A)_{RID, ORCID}
Source Title	Virus Research. - : Elsevier - ISSN 0168-1702 Roč. 149, č. 1 (2010), s. 119-123
Number of pages	5 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Tahyna virus ; Bunyavirus ; california group ; genetic variability ; virulence
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z60220518 - PAU-O, BC-A (2005-2011)
UT WOS	000276341900017
DOI	10.1016/j.virusres.2010.01.005
Annotation	Tahyna virus (TAHV), a mosquito-borne bunyavirus (California group), is frequently associated with inapparent or influenza-like (Valtice fever) infections in humans. Field TAHV strains exhibit a high variability in their biological properties with respect to virulence for laboratory mouse, temperature-sensitivity or character of plaques in cell culture. We analyzed complete nucleotide sequences of the small (S) and medium (M) genomic segments of field TAHV strains with different combinations of phenotypic markers. S segment was highly conservative in all analyzed TAHV strains. Within the M segment, the highest variability was observed in the G(C) gene encoding viral envelope protein and to a less extent also in the NSm gene. However, 5' and 3' non-coding regions of M segment, as well as in G(N) gene exhibited highly conservative pattern, indicating its functional importance, but minor or no role in the determination of biological properties of TAHV field strains.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2011

Number of the records: 1