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Characterization of ferritin 2 for the control of tick infestations
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SYSNO ASEP 0342866 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Characterization of ferritin 2 for the control of tick infestations Author(s) Hajdušek, Ondřej (BC-A) RID, ORCID
Almazán, C. (MX)
Loosová, Gabriela (BC-A)
Villar, M. (ES)
Canales, M. (ES)
Grubhoffer, L. (CZ)
Kopáček, Petr (BC-A) RID, ORCID
de la Fuente, J. (ES)Source Title Vaccine. - : Elsevier - ISSN 0264-410X
Roč. 28, č. 17 (2010), s. 2993-2998Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords tick ferritin 2 ; tick-protective vaccine Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA600960910 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000276877900011 DOI 10.1016/j.vaccine.2010.02.008 Annotation Tick iron metabolism pathway was targeted in an effort to identify new tick protective antigens. Recombinant Ixodes ricinus (IrFER2) and Rhipicephalus microplus (RmFER2) ferritin 2 proteins were expressed in Escherichia coli and used to immunize rabbits and cattle, respectively. Vaccination with IrFER2 reduced I. ricinus tick numbers, weight and fertility in rabbits with an overall vaccine efficacy (E) of 98%. Control of cattle tick, R. microplus and Rhipicephalus annulatus infestations was obtained in vaccinated cattle with overall E of 64% and 72%, respectively. Notably, the efficacy of the RmFER2 vaccine was similar to that obtained with Bm86 against R. microplus. These collective results demonstrated the feasibility of using ferritin 2 to develop vaccines for the control of tick infestations. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
Number of the records: 1