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Oxidation Changes Physical Properties of Phospholipid Bilayers: Fluorescence Spectroscopy and Molecular Simulations

SYSNO ASEP	0342762
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Oxidation Changes Physical Properties of Phospholipid Bilayers: Fluorescence Spectroscopy and Molecular Simulations
Author(s)	Beranová, Lenka (UFCH-W) Cwiklik, Lukasz (UOCHB-X)_{RID, ORCID} Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Hof, Martin (UFCH-W)_{RID, ORCID} Jungwirth, Pavel (UOCHB-X)_{RID, ORCID}
Source Title	Langmuir. - : American Chemical Society - ISSN 0743-7463 Roč. 26, č. 9 (2010), s. 6140-6144
Number of pages	5 s.
Language	eng - English
Country	US - United States
Keywords	oxidized phospholipides ; membranes ; fluorescence spectroscopy
Subject RIV	CF - Physical ; Theoretical Chemistry
R&D Projects	LC512 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LC06063 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GEMEM/09/E006 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40400503 - UFCH-W (2005-2011)
	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000276969700014
DOI	10.1021/la100657a
Annotation	Physical properties of oxidized phospholipid (OxPL) membranes consisting of binary mixtures of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 10 mol% of one of two OxPLs, 1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine (PGPC) or 1-palmitoyl-2-(5'-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC), were investigated experimentally and computationally. Fluorescence solvent relaxation (SR) and fluorescence correlation spectroscopy z-scan (FCS z-scan) show increased headgroup hydration and mobility, and faster lateral diffusion in POPC membrane upon addition of OxPLs. The magnitudes of both effects arc distinct for each of the two OxPLs. Molecular dynamics simulations corroborate the experimental findings, providing at the same time a detailed molecular interpretation in terms of changes in bilayer structure and phospholipid orientation.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2011

Number of the records: 1