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Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation
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SYSNO ASEP 0342537 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation Author(s) Pirnik, Z. (SK)
Maixnerová, Jana (UOCHB-X)
Matyšková, Resha (UOCHB-X)
Koutová, Darja (UOCHB-X)
Železná, Blanka (UOCHB-X) RID, ORCID
Maletínská, Lenka (UOCHB-X) RID, ORCID
Kiss, A. (SK)Number of authors 7 Source Title Peptides. - : Elsevier - ISSN 0196-9781
Roč. 31, č. 1 (2010), s. 139-144Number of pages 6 s. Language eng - English Country US - United States Keywords cholecystokinin ; CART ; hypocretin ; Fos peptide Subject RIV CE - Biochemistry R&D Projects GA303/05/0614 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000274375500019 DOI 10.1016/j.peptides.2009.09.035 Annotation The aim of this study was to determine the impact of two anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons located in the arcuate (ARC) and ventromedial (VMN) nuclei and hypocretin (Hcrt) synthesizing neurons located in the lateral hypothalamic area (LHA). After overnight starvation, male C57Bl/6 mice received in the morning saline (SAL), CCK (4 µg/kg, i.p.), CART peptide (0.1 µg/mice, i.c.v.) or CCK followed 5 minutes later by CART peptide. After 60 min, the presence of Fos or Fos-Hcrt immunostainings signalized the effect of treatments on the cell activity in ARC and VMN, as well as Hcrt cell activity in the LHA. The results indicate that CCK may modify the effect of CART peptide and thus substantially influence the activity of neurons in the hypothalamic structures involved in the food intake regulation. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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