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New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach
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SYSNO ASEP 0342527 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title New Insights into the Genetic Control of Gene Expression using a Bayesian Multi-tissue Approach Author(s) Petretto, E. (GB)
Bottolo, L. (GB)
Langley, S. R. (GB)
Heinig, M. (DE)
McDermott-Roe, Ch. (GB)
Sarwar, R. (GB)
Pravenec, Michal (FGU-C) RID, ORCID
Hübner, N. (DE)
Aitman, T. J. (GB)
Cook, S.A. (GB)
Richardson, S. (GB)Source Title PLoS Computational Biology - ISSN 1553-734X
Roč. 6, č. 4 (2010), e1000737Number of pages 13 s. Language eng - English Country US - United States Keywords expression profiles ; Bayesian multi-tissue approach ; genetical genomics Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/08/0166 GA ČR - Czech Science Foundation (CSF) 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP301/10/0290 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000278125300013 DOI 10.1371/journal.pcbi.1000737 Annotation To uncover complex genetic regulatory mechanisms controlling gene expression at the whole organism’s level, it is essential to develop appropriate analytical methods for the analysis of genome-wide genetic polymorphisms and gene expression profiles simultaneously in multiple tissues. This paper presents a novel, fully integrated Bayesian approach for mapping the genetic components of gene expression within and across multiple tissues Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2011
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