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Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency
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SYSNO ASEP 0342427 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency Author(s) Hlaváček, Jan (UOCHB-X)
Pícha, Jan (UOCHB-X) RID, ORCID
Vaněk, Václav (UOCHB-X) RID, ORCID
Jiráček, Jiří (UOCHB-X) RID, ORCID
Slaninová, Jiřina (UOCHB-X)
Fučík, Vladimír (UOCHB-X) RID
Buděšínský, Miloš (UOCHB-X) RID, ORCID
Gilner, D. (US)
Holz, R. C. (US)Number of authors 9 Source Title Amino Acids. - : Springer - ISSN 0939-4451
Roč. 38, č. 4 (2010), s. 1155-1164Number of pages 10 s. Language eng - English Country AT - Austria Keywords ArgE inhibitors ; acetylornithine derivatives ; synthesis ; inhibitory and antiviral activity Subject RIV CC - Organic Chemistry R&D Projects IAA400550614 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000276423300020 DOI 10.1007/s00726-009-0326-8 Annotation A series of Nα-acyl(alkyl) and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized and analyzed for their potency toward the bacterial enzyme N (alpha)-acetyl-L-ornithine deacetylase. N (alpha)-chloroacetyl-L-ornithine was the best inhibitor tested providing an IC50 value of 85 (mu)M. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
Number of the records: 1