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Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata
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SYSNO ASEP 0342382 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata Author(s) Čeřovský, Václav (UOCHB-X) RID, ORCID
Žďárek, Jan (UOCHB-X)
Fučík, Vladimír (UOCHB-X) RID
Monincová, Lenka (UOCHB-X)
Voburka, Zdeněk (UOCHB-X)
Bém, R. (CZ)Number of authors 6 Source Title Cellular and Molecular Life Sciences - ISSN 1420-682X
Roč. 67, č. 3 (2010), s. 455-466Number of pages 12 s. Language eng - English Country CH - Switzerland Keywords antimicrobial peptide ; insect defensin ; Lucilia sericata ; Maggot therapy Subject RIV CC - Organic Chemistry R&D Projects GA203/08/0536 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000273351900010 DOI 10.1007/s00018-009-0194-0 Annotation A novel homolog of insect defensin designated lucifensin (Lucilia defensin) was purified from the extracts of various tissues of the green bottle fly (Lucilia sericata) larvae and from their excretions/secretions. The primary sequence of this peptide of 40 residues and three intramolecular disulfide bridges was determined by ESI-QTOF mass spectrometry and Edman degradation. It is proposed that lucifensin is that long-sought larger molecular weight antimicrobial factor of the Lucilia sericata excretions/secretions supposed to be effective against pathogenic elements of the wound microbial flora during the medicinal process known as maggot therapy. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
Number of the records: 1