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New coupling strategy for radionuclide labeling of synthetic polymers
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SYSNO ASEP 0342352 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title New coupling strategy for radionuclide labeling of synthetic polymers Author(s) Hrubý, Martin (UMCH-V) RID, ORCID
Kučka, Jan (UMCH-V) RID, ORCID
Nováková, Michaela (UMCH-V) RID
Macková, Hana (UMCH-V) RID
Vetrík, Miroslav (UMCH-V) RID, ORCIDSource Title Applied Radiation and Isotopes. - : Elsevier - ISSN 0969-8043
Roč. 68, č. 2 (2010), s. 334-339Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords polymer ; radionuclide ; labeling Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA202/09/2078 GA ČR - Czech Science Foundation (CSF) 1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000276117500018 DOI 10.1016/j.apradiso.2009.11.039 Annotation We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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