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Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate
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SYSNO ASEP 0342344 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate Author(s) Urban, M. (US)
Joubert, Nicolas (UOCHB-X)
Purse, B. W. (US)
Hocek, Michal (UOCHB-X) RID, ORCID
Kuchta, R. D. (US)Number of authors 5 Source Title Biochemistry. - : American Chemical Society - ISSN 0006-2960
Roč. 49, č. 4 (2010), s. 727-735Number of pages 9 s. Language eng - English Country US - United States Keywords C-nucleosides ; DNA polymerase ; primase ; mechanism Subject RIV CC - Organic Chemistry R&D Projects LC512 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) IAA400550902 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000273831500009 DOI 10.1021/bi9019516 Annotation We used an extensive series of purine and pyrimidine nucleotide analogues to provide further insights into the mechanism by which primase chooses whether or not to polymerize a NTP. The data demonstrate that human primase strongly depends on Watson-Crick hydrogen bonds for efficient nucleotide polymerization. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2011
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