Number of the records: 1

6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents

SYSNO ASEP	0342338
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents
Author(s)	Nauš, Petr (UOCHB-X)_RID Pohl, Radek (UOCHB-X)_{RID, ORCID} Votruba, Ivan (UOCHB-X)_RID Džubák, P. (CZ) Hajdúch, M. (CZ) Ameral, R. (US) Birkuš, G. (US) Wang, T. (US) Ray, A. S. (US) Mackman, R. (US) Cihlar, T. (US) Hocek, Michal (UOCHB-X)_{RID, ORCID}
Number of authors	12
Source Title	Journal of Medicinal Chemistry. - : American Chemical Society - ISSN 0022-2623 Roč. 53, č. 1 (2010), s. 460-470
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	nucleosides ; 7-deazapurines ; cross-coupling ; cytostatic activity
Subject RIV	CC - Organic Chemistry
R&D Projects	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1QS400550501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000273268300039
DOI	10.1021/jm901428k
Annotation	A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared and showed to possess significant cytostatic effect in nanomolar concentrations. Intracellular phosphorylation to mono- and triphosphates, and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2011

Number of the records: 1