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Thermoresponsive micelles for radionuclide delivery
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SYSNO ASEP 0342223 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Thermoresponsive micelles for radionuclide delivery Author(s) Hrubý, Martin (UMCH-V) RID, ORCID
Filippov, Sergey K. (UMCH-V) RID, ORCID, SAI
Pánek, Jiří (UMCH-V) RID, ORCID
Nováková, Michaela (UMCH-V) RID
Macková, Hana (UMCH-V) RID
Kučka, Jan (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RIDSource Title Abstract Book. - Egmond aan Zee : University of Twente, 2010 / Engbersen J.F.J. - ISBN 978-90-365-3007-1 Pages s. 216-218 Number of pages 3 s. Action European Symposium on Controlled Drug Delivery /11./ Event date 07.04.2010-09.04.2010 VEvent location Egmond aan Zee Country NL - Netherlands Event type WRD Language eng - English Country NL - Netherlands Keywords micelles ; drug delivery systems ; thermoresponsive polymers Subject RIV FR - Pharmacology ; Medidal Chemistry R&D Projects KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GPP207/10/P054 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40500505 - UMCH-V (2005-2011) Annotation We have synthesized and characterized a thermoresponsive micellar radionuclide delivery systems based on ABA triblock copolymers poly[2-methyl-2-oxazoline - block - (2-isopropyl-2-oxazoline - co - 2-butyl-2-oxazoline) - block - 2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter ~ 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2011
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