Number of the records: 1

Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

SYSNO ASEP	0342116
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents
Author(s)	Kořínek, Miroslav (FGU-C) Sedláček, Miloslav (FGU-C) Cais, Ondřej (FGU-C) Dittert, Ivan (FGU-C)_ORCID Vyklický ml., Ladislav (FGU-C)_{RID, ORCID, SAI}
Source Title	Neuroscience. - : Elsevier - ISSN 0306-4522 Roč. 165, č. 3 (2010), s. 736-748
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	hypothermia ; patch-clamp recording
Subject RIV	ED - Physiology
R&D Projects	1M0517 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA309/07/0271 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000274002600011
DOI	10.1016/j.neuroscience.2009.10.058
Annotation	The article focuses on the problematic of temperature dependence of deactivation of native N-Methyl-D-Aspartate (NMDA) receptors in neuronal cultures and the temperature dependence of excitatory postsynaptic currents mediated by synaptic NMDA receptors in rat cortical slices. Our electrophysiology experiments found that both native as well as synaptic receptors exhibit significantly weaker temperature dependence compared to recombinant GluN1/GluN2B NMDA receptors. Synaptic NMDA receptors have characteristics of receptors with low desensitization (20%). Double exponential time course of NMDA receptor deactivation originates mainly from dissociation of agonist and desensitization
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2011

Number of the records: 1