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Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization

SYSNO ASEP	0341837
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Proteome Mining of Human Follicular Fluid Reveals a Crucial Role of Complement Cascade and Key Biological Pathways in Women Undergoing in Vitro Fertilization
Author(s)	Jarkovská, Karla (UZFG-Y)_RID Martinková, Jiřina (UZFG-Y) Lišková, Lucie (UZFG-Y) Halada, Petr (MBU-M)_{RID, ORCID} Moos, J. (CZ) Rezábek, K. (CZ) Gadher, S. J. (CH) Kovářová, Hana (UZFG-Y)_{RID, ORCID}
Source Title	Journal of Proteome Research. - : American Chemical Society - ISSN 1535-3893 Roč. 9, č. 3 (2010), s. 1289-1301
Number of pages	13 s.
Language	eng - English
Country	US - United States
Keywords	Human follicular fluid ; plasma ; assisted reproduction
Subject RIV	FK - Gynaecology, Childbirth
R&D Projects	NS9781 GA MZd - Ministry of Health (MZ)
	1QS500450568 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000275088100012
DOI	10.1021/pr900802u
Annotation	The primary aim of this study was to search for specific differences in protein composition of human follicular fluid (HFF) and plasma in order to identify proteins that accumulate or are absent in HFF. Depletion of abundant proteins combined with multidimensional protein fractionation allowed the study of middle- and lower-abundance proteins. Paired comparison study examining HFF with plasma/serum from women undergoing successful IVF revealed important differences in the protein composition which may improve our knowledge of the follicular microenvironment and its biological role. This study showed involvement of innate immune function of complement cascade in HFF Complement inhibition and the presence of C-terminal fragment of perlecan suggested possible links to angiogenesis which is a vital process in folliculogenesis and placental development. Differences in proteins associated with blood coagulation were also found in the follicular milieu.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2011

Number of the records: 1