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DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway
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SYSNO ASEP 0341479 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway Author(s) Ullmannová-Benson, Veronika (MBU-M) RID
Guan, M. (US)
Zhou, X. G. (US)
Tripathi, V. (US)
Yang, V. (US)
Zimonjic, D. B. (US)
Popescu, C. (US)Source Title Leukemia. - : Springer - ISSN 0887-6924
Roč. 23, č. 2 (2009), s. 383-390Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords multiple myeloma ; tumor suppressor gene ; promoter methylation Subject RIV EC - Immunology CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000263312300020 DOI 10.1038/leu.2008.285 Annotation DLC1 (deleted in liver cancer 1), a tumor suppressor gene that encodes a RhoGTPase-activating protein, is recurrently downregulated or silenced in various solid tumors and hematological malignancies because of epigenetic modifications or genomic deletion. Here, we identified DLC1 promoter hypermethylation in 43 out of 44 multiple myeloma (MM) cell lines, which resulted in downregulation or silencing of DLC1 in 41 samples Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
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