Number of the records: 1
WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance
- 1.
SYSNO ASEP 0341448 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance Author(s) Otahalová, E. (CZ)
Ullmannová-Benson, Veronika (MBU-M) RID
Klamová, H. (CZ)
Haškovec, C. (CZ)Source Title Neoplasma - ISSN 0028-2685
Roč. 56, č. 5 (2009), s. 393-397Number of pages 5 s. Language eng - English Country SK - Slovakia Keywords Imatinib ; drug resistance ; cml Subject RIV EC - Immunology CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000269333200004 DOI 10.4149/neo_2009_05_393 Annotation The determination of patient's resistance to a particular drug contributes to more efficient therapeutical approach. The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes. To examine the resistance we implemented an in vitro cultivation of the primary cells of 48 CML patients with Imatinib Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
Number of the records: 1