Number of the records: 1  

Structure of the motor subunit of type I restriction-modification complex EcoR124I

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    SYSNO ASEP0341137
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleStructure of the motor subunit of type I restriction-modification complex EcoR124I
    Author(s) Lapkouski, Mikalai (UEK-B)
    Number of authors7
    Source TitleNature Structural & Molecular Biology. - : Nature Publishing Group - ISSN 1545-9993
    Roč. 1, č. 16 (2009), s. 94-95
    Number of pages2 s.
    Languageeng - English
    CountryUS - United States
    KeywordsSWI2/SNF2 ATPASE ; DNA ; ENDONUCLEASE
    Subject RIVCE - Biochemistry
    CEZAV0Z60870520 - UEK-B (2005-2011)
    UT WOS000262267600019
    AnnotationType I restriction-modification enzymes act as conventional adenine methylases on hemimethylated DNAs, but unmethylated recognition targets induce them to translocate thousands of base pairs before cleaving distant sites nonspecifically. The first crystal structure of a type I motor subunit responsible for translocation and cleavage suggests how the pentameric translocating complex is assembled and provides a structural framework for translocation of duplex DNA by RecA-like ATPase motors.
    WorkplaceGlobal Change Research Institute
    ContactNikola Šviková, svikova.n@czechglobe.cz, Tel.: 511 192 268
    Year of Publishing2010
Number of the records: 1  

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