Genetic interaction between Lrp6 and Wnt5a during mouse development

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SYSNO ASEP	0341084
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Genetic interaction between Lrp6 and Wnt5a during mouse development
Author(s)	Andersson, E. (SE) Bryjová, Lenka (BFU-R) Biris, K. (US) Yamaguchi, T.P. (US) Arenas, E. (SE) Bryja, Vítězslav (BFU-R)_{RID, ORCID}
Number of authors	6
Source Title	Developmental Dynamics. - : Wiley - ISSN 1058-8388 Roč. 239, č. 1 (2010), s. 237-245
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	Wnt5a ; Lrp6 ; somitogenesis
Subject RIV	BO - Biophysics
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000273703900021
DOI	10.1002/dvdy.22101
Annotation	Lrp6 is generally described as a receptor required for signal transduction in the Wnt/b-catenin pathway. Wnt5a, however, is a Wnt ligand which usually does not activate Wnt/b-catenin but rather activates non-canonical Wnt signaling. Here we describe phenotypes found in Wnt5a/Lrp6 compound mutant mice, including a worsening of individual Wnt5a or Lrp6 loss of function phenotypes. Lrp6 haploinsufficiency in a Wnt5a-/- background caused spina bifida and exacerbated posterior truncation.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1