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Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis
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SYSNO ASEP 0341047 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Enhanced levels of mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 in patients with Azheimer disease and multiple sclerosis Author(s) Krištofíková, Z. (CZ)
Bocková, Markéta (URE-Y)
Hegnerová, Kateřina (URE-Y)
Bartoš, A. (CZ)
Klaschka, J. (CZ)
Říčný, J. (CZ)
Řípová, D. (CZ)
Homola, Jiří (URE-Y) RIDSource Title Molecular BioSystems - ISSN 1742-206X
Roč. 10, č. 5 (2009), s. 1174-1179Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords 17beta-HSD 10 ; Alzheimer disease ; SPR sensor Subject RIV JB - Sensors, Measurment, Regulation R&D Projects NR9322 GA MZd - Ministry of Health (MZ) CEZ AV0Z20670512 - URE-Y (2005-2011) UT WOS 000269835400010 DOI 10.1039/b904799a Annotation This paper describes detection of mitochondrial 17-HSD10 enzyme using a surface plasmon resonance (SPR) biosensor and ELISA method. 17-HSD10 enzyme is involved in pathogenesis of Alzheimer disease (AD) and represents a potential target for AD diagnostics. It was demonstrated that the reported SPR biosensor is capable of detecting 17β-HSD10/Aβs complex in CSF samples and it was revealed the patients with AD exhibited elavated levels of 17β-HSD10/Aβs complex compared to the controls. Workplace Institute of Radio Engineering and Electronics Contact Petr Vacek, vacek@ufe.cz, Tel.: 266 773 413, 266 773 438, 266 773 488 Year of Publishing 2010
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