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Dissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides

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    SYSNO ASEP0340845
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleDissociation of nystatin and amphotericin analogues: characterization of minor anti-fungal macrolides
    Author(s) Ulrych, Aleš (MBU-M) RID
    Derrick, P.J. (NZ)
    Adámek, F. (CZ)
    Novák, Petr (MBU-M) RID, ORCID
    Lemr, Karel (MBU-M) RID, ORCID
    Havlíček, Vladimír (MBU-M) RID, ORCID
    Source TitleEuropean Journal of Mass Spectrometry. - : Sage - ISSN 1469-0667 - ISSN 1365-0718
    Roč. 16, č. 1 (2010), s. 73-80
    Number of pages8 s.
    Languageeng - English
    CountryGB - United Kingdom
    Keywordsantibiotics ; nystatin ; amphotericin
    Subject RIVEE - Microbiology, Virology
    R&D ProjectsLC07017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    CEZAV0Z50200510 - MBU-M (2005-2011)
    UT WOS000274290200008
    DOI10.1255/ejms.1027
    AnnotationTandem mass spectrometry combined with Fourier transform ion cyclotron resonance (FTICR) has been the basis for rationalizing the fragmentation mechanisms of antifungal macrolides nystatin A1, amphotericin B and pimaricin. The positive ion mass spectra were not informative, however, the dissociation of deprotonated molecules led to structurally significant ring-opened fragments. Using this approach of tandem FTICR mass spectrometry (MS/MS) and electrospray ionization (ESI) coupled with high-performance liquid chromatography (HPLC), eleven macrolide natural analogues or degradation products were characterized in the nystatin mixture
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2010
Number of the records: 1  

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