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Antioxidant and antiviral activities of silybin fatty acid conjugates

SYSNO ASEP	0340841
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Antioxidant and antiviral activities of silybin fatty acid conjugates
Author(s)	Gažák, Radek (MBU-M)_{RID, ORCID} Purchartová, Kateřina (MBU-M)_RID Marhol, Petr (MBU-M)_RID Živná, L. (CZ) Sedmera, Petr (MBU-M) Valentová, K. (CZ) Kato, N. (JP) Matsumura, H. (JP) Kaihatsu, K. (JP) Křen, Vladimír (MBU-M)_{RID, ORCID}
Source Title	European Journal of Medicinal Chemistry. - : Elsevier - ISSN 0223-5234 Roč. 45, č. 3 (2010), s. 1059-1067
Number of pages	9 s.
Language	eng - English
Country	FR - France
Keywords	Influenza virus ; silibinin ; silybin
Subject RIV	CC - Organic Chemistry
R&D Projects	KJB400200701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	OC08049 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LC06010 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000275404900025
DOI	10.1016/j.ejmech.2009.11.056
Annotation	wo selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2011

Number of the records: 1