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HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha
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SYSNO ASEP 0340698 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha Author(s) Štros, Michal (BFU-R) RID, ORCID
Muselíková Polanská, Eva (BFU-R)
Štruncová, S. (CZ)
Pospíšilová, Š. (CZ)Number of authors 4 Source Title Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048
Roč. 37, č. 7 (2009), s. 2070-2086Number of pages 17 s. Language eng - English Country GB - United Kingdom Keywords HMGB ; topoisomerase IIalpha ; cellular expression Subject RIV BO - Biophysics R&D Projects IAA400040702 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000265741600002 DOI 10.1093/nar/gkp067 Annotation We have demonstrated that HMGB1, but not a mutant of HMGB1 incapable of DNA bending, up-regulated the activity of the topo IIalpha promoter in human cells that lack functional retinoblastoma protein pRb. Our experiments suggested a mechanism of up-regulation of cellular expression of topo IIalpha by HMGB1/2 in pRb-negative cells by modulation of binding of transcription factor NF-Y to the topo IIalpha promoter. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
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