Number of the records: 1

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells

SYSNO ASEP	0340647
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells
Author(s)	Jendželovský, R. (SK) Mikeš, J. (SK) Koval, J. (SK) Souček, Karel (BFU-R)_{RID, ORCID} Procházková, Jiřina (BFU-R)_{RID, ORCID} Kello, M. (SK) Sačková, V. (SK) Hofmanová, Jiřina (BFU-R)_{RID, ORCID} Kozubík, Alois (BFU-R)_{RID, ORCID} Fedoročko, P. (SK)
Number of authors	10
Source Title	Photochemical & Photobiological Sciences - ISSN 1474-905X Roč. 8, č. 12 (2009), s. 1716-1723
Number of pages	8 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	hypericin ; photodynamic therapy ; ABC transporters
Subject RIV	BO - Biophysics
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000272142300010
DOI	10.1039/b9pp00086k
Annotation	We have investigated the efficiency of a combined modality approach employing 24 h pretreatment of relatively PDT-resistant HT-29 colon adenocarcinoma cells with proadifen followed by HY-PDT. Since significant accumulation of hypericin was found to be a principal factor responsible for ROS induction and therefore higher efficiency of HY-PDT, involvement of ABC transporter system was evaluated.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1