The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets

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SYSNO ASEP	0340614
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The potential of the cruciform structure formation as an important factor influencing p53 sequence-specific binding to natural DNA targets
Author(s)	Brázdová Jagelská, Eva (BFU-R)_{RID, ORCID} Pivoňková, Hana (BFU-R)_ORCID Fojta, Miroslav (BFU-R)_{RID, ORCID} Brázda, Václav (BFU-R)_{RID, ORCID}
Number of authors	4
Source Title	Biochemical and Biophysical Research Communications. - : Elsevier - ISSN 0006-291X Roč. 391, č. 3 (2010), s. 1409-1414
Number of pages	6 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	scDNA ; plasmid pBluescript SK ; linear DNA
Subject RIV	BO - Biophysics
R&D Projects	GP301/07/P160 GA ČR - Czech Science Foundation (CSF)
	GP204/07/P476 GA ČR - Czech Science Foundation (CSF)
	IAA500040701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000274097800021
DOI	10.1016/j.bbrc.2009.12.076
Annotation	P53 binding to DNA is strongly influenced by DNA topology. We investigated the cruciform structure formation of various inverted repeats in p53-responsive sequences from p21, RGC, mdm2 and GAAD45 promoters under negative superhelical stress and analyzed the effects of these DNA topology changes on p53-DNA binding.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1